Classical molecular dynamics simulations utilizing the Martini coarse-grained pressure subject had been carried out to review oil nanodroplets surrounded by fungal hydrophobin (HP) proteins in seawater. The class I EAS and the category II HFBII HPs had been studied together with two mannequin oils, specifically, benzene and n-decane. Both HPs exhibit free vitality minima on the oil-seawater interface, which is deeper in benzene in comparison with the n-decane techniques.
Larger constraint forces are required to maintain each HPs inside the n-decane part in comparison with inside benzene, with HFBII being extra affine to benzene in comparison with EAS. Smaller floor tensions are noticed at benzene-seawater interfaces coated with HPs in comparison with their n-decane counterparts. In the latter the floor rigidity stays unchanged upon will increase in the focus of HPs, whereas in benzene techniques including extra HPs result in decreases in floor rigidity.
EAS has a bigger tendency to cluster collectively in the interface in comparison with HFBII, with each HPs having bigger coordination numbers when surrounding benzene droplets in comparison with when they’re round n-decane nanoblobs. The HP-oil nanostructures in seawater examined have radii of gyration ranging between 2 and 12 nm, the place the n-decane buildings are bigger and have extra irregular shapes in comparison with the benzene techniques.
The n-decane molecules inside the nanostructures type a compact spherical core, with the HPs partially masking its floor and clustering collectively, conferring irregular shapes to the nanostructures. The EAS with n-decane buildings are bigger and have extra irregular shapes in comparison with their HFBII counterparts. In distinction, in the HP-benzene buildings each HPs are likely to penetrate the oil half of the droplet.
The HFBII-benzene buildings having the bigger oil/HP ratios examined are typically extra compact and spherical in comparison with their EAS counterparts; nonetheless, some of the HFBII-benzene techniques which have smaller oil/HP ratios have a extra elongated construction in comparison with their EAS counterparts. This simulation examine supplies insights into HP-oil nanostructures which are smaller than the oil droplets and fuel bubbles lately studied in experiments and, thus, could be difficult to look at with experimental methods.
A pure product of acteoside ameliorate kidney damage in diabetes db/db mice and HK-2 cells by way of regulating NADPH/oxidase-TGF-β/Smad signaling pathway
This examine was designed to research the protecting results and mechanisms of acteoside on DKD in diabetes male db/db mice and excessive glucose-induced HK-2 cells. The diabetes db/db mice had been divided randomly into mannequin group, metformin group, irbesartan group, and acteoside group. We noticed the pure product of acteoside exhibiting a major impact in renal safety by means of analyzing of biochemical indicators and endogenous metabolites, histopathological observations, and western blotting. HK-2 cells subjected to excessive glucose had been used in invitro experiments.
The molecular mechanisms of them had been investigated by RT-PCR and western blot. Acteoside prevents excessive glucose-induced HK-2 cells and diabetes db/db mice by inhibiting NADPH/oxidase-TGF-β/Smad signaling pathway. Acteoside regulated the disturbed metabolic pathway of lipid metabolism, glyoxylate and dicarboxylate metabolism, and arachidonic acid metabolism. We found the pure product of acteoside exhibiting a major impact in renal safety. This examine paved the way in which for additional exploration of pathogenesis, early analysis, and growth of a brand new therapeutic agent for DKD.
Photophysical properties of heavy atom containing tetrasulfonyl phthalocyanines as doable photosensitizers in photodynamic remedy
The excitation energies, singlet-triplet vitality hole and spin-orbit coupling constants for Zn-, GaCl-, Pd-, and Pt- tetrasulfonyl phthalocyanines complexes (ZnComputer, GaClPc, PdComputer, and PtComputer) have been computed by utilizing the density purposeful idea and using the M06 exchange-correlation purposeful. Results present that these techniques possess attention-grabbing photophysical properties, which make them doable photosensitizers to be proposed in photodynamic remedy (PDT).
Absorption energies of all of the complexes examined have been discovered falling contained in the so-called therapeutic window (550-800 nm). Singlet-triplet vitality hole values are larger than these required for the manufacturing of cytotoxic molecular oxygen and the spin-orbit coupling constants are corresponding to to make sure an environment friendly spin orbit intersystem crossing. The obtained information are in step with the experimental oxygen singlet quantum yields. The platinum advanced seems to be the simplest candidate to suggest for PDT.
Purine adducts as a presumable lacking hyperlink for aristolochic acid nephropathy associated mobile vitality disaster, potential anti-fibrotic prevention and therapy
Aristolochic acid nephropathy (AAN) is a progressive exposome-induced illness characterised by tubular atrophy and fibrosis culminating in end-stage renal illness and malignancies. The molecular mechanisms of the vitality disaster as a putative trigger of fibrosis haven’t but been elucidated. In gentle of the truth that aristolochic acid (AA) varieties DNA and RNA adducts by covalent binding of AA metabolites to exocyclic amino teams of (deoxy)adenosine and (deoxy)guanosine, we hypothesize right here that related AA adducts might exist with different purine-containing molecules.
CHAPS (Molecular Biology Grade) |
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| CE114 | GeneOn | 1 g | EUR 66 |
CHAPS (Molecular Biology Grade) |
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| CE115 | GeneOn | 5 g | EUR 157.2 |
CHAPS (Molecular Biology Grade) |
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| CE116 | GeneOn | 25 g | EUR 492 |
DAPI (Molecular Biology Grade) |
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| CE117 | GeneOn | 5 mg | EUR 72 |
DAPI (Molecular Biology Grade) |
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| CE118 | GeneOn | 25 mg | EUR 159.6 |
DAPI (Molecular Biology Grade) |
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| CE119 | GeneOn | 100 mg | EUR 382.8 |
Dimethylsulfoxide (Molecular Biology Grade) |
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| CE120 | GeneOn | 100 ml | EUR 66 |
Dimethylsulfoxide (Molecular Biology Grade) |
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| CE121 | GeneOn | 500 ml | EUR 110.4 |
DTT (Molecular Biology Grade) |
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| CE131 | GeneOn | 5 g | EUR 93.6 |
DTT (Molecular Biology Grade) |
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| CE132 | GeneOn | 10 g | EUR 133.2 |
DTT (Molecular Biology Grade) |
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| CE133 | GeneOn | 25 g | EUR 243.6 |
Glycine (Molecular Biology Grade) |
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| CE158 | GeneOn | 1 kg | EUR 84 |
Glycine (Molecular Biology Grade) |
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| CE159 | GeneOn | 5 kg | EUR 228 |
HEPES (Molecular Biology Grade) |
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| CE171 | GeneOn | 100 g | EUR 98.4 |
HEPES (Molecular Biology Grade) |
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| CE172 | GeneOn | 500 g | EUR 268.8 |
HEPES (Molecular Biology Grade) |
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| CE173 | GeneOn | 1 kg | EUR 424.8 |
Lysozyme (Molecular Biology Grade) |
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| CE188 | GeneOn | 1 g | EUR 70.8 |
Lysozyme (Molecular Biology Grade) |
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| CE189 | GeneOn | 10 g | EUR 247.2 |
NAD (Molecular Biology Grade) |
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| CE196 | GeneOn | 1 g | EUR 72 |
NAD (Molecular Biology Grade) |
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| CE197 | GeneOn | 5 g | EUR 165.6 |
NBT (Molecular Biology Grade) |
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| CE209 | GeneOn | 1 g | EUR 123.6 |
NBT (Molecular Biology Grade) |
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| CE210 | GeneOn | 5 g | EUR 360 |
Tris (Molecular Biology Grade) |
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| CE237 | GeneOn | 500 g | EUR 106.8 |
Tris (Molecular Biology Grade) |
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| CE238 | GeneOn | 1 kg | EUR 153.6 |
Tris (Molecular Biology Grade) |
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| CE239 | GeneOn | 5 kg | EUR 535.2 |
Tween20 (Molecular Biology Grade) |
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| CE242 | GeneOn | 1 l | EUR 106.8 |
Water (Molecular Biology Grade) |
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| CE243 | GeneOn | 500 ml | EUR 62.4 |
Water (Molecular Biology Grade) |
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| CE244 | GeneOn | 1 l | EUR 67.2 |
100mL Molecular Biology Grade |
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| 46-000-CI | Scientific Laboratory Supplies | PK6 | EUR 70.68 |
500mL Molecular Biology Grade |
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| 46-000-CV | Scientific Laboratory Supplies | PK6 | EUR 124.26 |
Ammonium sulfate (Molecular Biology Grade) |
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| CE105 | GeneOn | 250 g | EUR 55.2 |
Ammonium sulfate (Molecular Biology Grade) |
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| CE106 | GeneOn | 1 kg | EUR 72 |
Ammonium sulfate (Molecular Biology Grade) |
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| CE107 | GeneOn | 5 kg | EUR 153.6 |
Bis-Acrylamid (Molecular Biology Grade) |
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| CE110 | GeneOn | 50 g | EUR 94.8 |
Bis-Acrylamid (Molecular Biology Grade) |
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| CE111 | GeneOn | 250 g | EUR 259.2 |
Formamide deionized (Molecular Biology Grade) |
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| CE145 | GeneOn | 500 ml | EUR 87.6 |
Formamide deionized (Molecular Biology Grade) |
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| CE146 | GeneOn | 1 l | EUR 120 |
Glycerol 87 % (Molecular Biology Grade) |
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| CE154 | GeneOn | 1 l | EUR 93.6 |
Glycerol waterfree (Molecular Biology Grade) |
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| CE155 | GeneOn | 500 ml | EUR 78 |
Glycerol waterfree (Molecular Biology Grade) |
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| CE156 | GeneOn | 1 l | EUR 102 |
Glycerol waterfree (Molecular Biology Grade) |
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| CE157 | GeneOn | 2.5 l | EUR 170.4 |
Guanidine - Hydrochloride (Molecular Biology Grade) |
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| CE160 | GeneOn | 100 g | EUR 93.6 |
Guanidine - Hydrochloride (Molecular Biology Grade) |
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| CE161 | GeneOn | 250 g | EUR 153.6 |
Guanidine - Hydrochloride (Molecular Biology Grade) |
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| CE162 | GeneOn | 500 g | EUR 232.8 |
Guanidine - Hydrochloride (Molecular Biology Grade) |
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| CE163 | GeneOn | 1 kg | EUR 352.8 |
Guanidine Thiocyanate (Molecular Biology Grade) |
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| CE164 | GeneOn | 100 g | EUR 86.4 |
Guanidine Thiocyanate (Molecular Biology Grade) |
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| CE165 | GeneOn | 500 g | EUR 192 |
Guanidine Thiocyanate (Molecular Biology Grade) |
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| CE166 | GeneOn | 1 kg | EUR 307.2 |
Urea Crystalline (Molecular Biology Grade) |
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| CE167 | GeneOn | 1 kg | EUR 72 |
Urea Crystalline (Molecular Biology Grade) |
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| CE168 | GeneOn | 5 kg | EUR 181.2 |
MOPS buffer (Molecular Biology Grade) |
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| CE194 | GeneOn | 100 g | EUR 102 |
MOPS buffer (Molecular Biology Grade) |
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| CE195 | GeneOn | 250 g | EUR 169.2 |
Sodium chloride (Molecular Biology Grade) |
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| CE205 | GeneOn | 500 g | EUR 62.4 |
Sodium chloride (Molecular Biology Grade) |
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| CE206 | GeneOn | 1 kg | EUR 70.8 |
Sodium chloride (Molecular Biology Grade) |
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| CE207 | GeneOn | 5 kg | EUR 123.6 |
Tris - Hydrochloride (Molecular Biology Grade) |
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| CE234 | GeneOn | 250 g | EUR 99.6 |
Tris - Hydrochloride (Molecular Biology Grade) |
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| CE235 | GeneOn | 500 g | EUR 144 |
Tris - Hydrochloride (Molecular Biology Grade) |
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| CE236 | GeneOn | 1 kg | EUR 223.2 |
TritonX-100 (Molecular Biology Grade) |
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| CE240 | GeneOn | 500 ml | EUR 67.2 |
TritonX-100 (Molecular Biology Grade) |
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| CE241 | GeneOn | 1 l | EUR 79.2 |
Water, Ultrapure Molecular Biology Grade |
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| 41024-4L | Biotium | 4L | EUR 145.2 |
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Description: Minimum order quantity: 1 unit of 4L |
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Tween 20, Molecular Biology Grade |
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| T9100-010 | GenDepot | 100ml | EUR 86.4 |
Tween 20, Molecular Biology Grade |
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| T9100-050 | GenDepot | 500ml | EUR 133.2 |
Tween 20, Molecular Biology Grade |
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| T9100-100 | GenDepot | 1L | EUR 160.8 |
1L Molecular Biology Grade Water |
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| 46-000-CM | Scientific Laboratory Supplies | PK6 | EUR 177.84 |
Water, distilled, GlenBiol™, suitable for molecular biology |
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| GK8512-1L | Glentham Life Sciences | 1 l | EUR 92.4 |
Agarose, low EEO, GlenBiol, suitable for molecular biology |
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| GE6258-100G | Glentham Life Sciences | 100 g | EUR 217.2 |
Phenol, (Carbolic acid) Double distilled for Molecular Biology |
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| PD0252 | Bio Basic | 500g | EUR 192.59 |
EDTA - Dinatriumsalz - Dihydrat (Molecular Biology Grade) |
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| CE135 | GeneOn | 250 g | EUR 72 |
EDTA - Dinatriumsalz - Dihydrat (Molecular Biology Grade) |
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| CE136 | GeneOn | 500 g | EUR 86.4 |
EDTA - Dinatriumsalz - Dihydrat (Molecular Biology Grade) |
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| CE137 | GeneOn | 1 kg | EUR 124.8 |
EDTA - Dinatriumsalz - Dihydrat (Molecular Biology Grade) |
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| CE138 | GeneOn | 5 kg | EUR 418.8 |
D(+)-Glucose waterfree (Molecular Biology Grade) |
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| CE148 | GeneOn | 500 g | EUR 67.2 |
D(+)-Glucose waterfree (Molecular Biology Grade) |
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| CE149 | GeneOn | 1 kg | EUR 75.6 |
D(+)-Glucose waterfree (Molecular Biology Grade) |
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| CE150 | GeneOn | 5 kg | EUR 180 |
Yeast extract powder (Molecular Biology Grade) |
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| CE169 | GeneOn | 500 g | EUR 133.2 |
Hyaluronidase Grade I (Molecular Biology Grade) |
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| CE174 | GeneOn | 1 g | EUR 232.8 |
Hyaluronidase Grade I (Molecular Biology Grade) |
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| CE175 | GeneOn | 5 g | EUR 920.4 |
Magnesium acetate - Tetrahydrate (Molecular Biology Grade) |
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| CE190 | GeneOn | 500 g | EUR 98.4 |
NADH - Disodium salt (Molecular Biology Grade) |
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| CE198 | GeneOn | 1 g | EUR 91.2 |
NADH - Disodium salt (Molecular Biology Grade) |
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| CE199 | GeneOn | 5 g | EUR 244.8 |
NADP - sodium salt (Molecular Biology Grade) |
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| CE200 | GeneOn | 250 mg | EUR 92.4 |
NADP - sodium salt (Molecular Biology Grade) |
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| CE201 | GeneOn | 1 g | EUR 190.8 |
NADPH - Tetrasodium salt (Molecular Biology Grade) |
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| CE202 | GeneOn | 25 mg | EUR 70.8 |
NADPH - Tetrasodium salt (Molecular Biology Grade) |
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| CE203 | GeneOn | 100 mg | EUR 126 |
NADPH - Tetrasodium salt (Molecular Biology Grade) |
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| CE204 | GeneOn | 500 mg | EUR 374.4 |
SSC Buffer (20X) (Molecular Biology Grade) |
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| CE229 | GeneOn | 1 l | EUR 86.4 |
XTT sodium salt (Molecular Biology Grade) |
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| CE250 | GeneOn | 100 mg | EUR 208.8 |
XTT sodium salt (Molecular Biology Grade) |
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| CE251 | GeneOn | 500 mg | EUR 612 |
Albumin fraction V (pH7,0) (Molecular Biology Grade) |
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| CE100 | GeneOn | 50 g | EUR 128.4 |
Albumin fraction V (pH7,0) (Molecular Biology Grade) |
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| CE101 | GeneOn | 100 g | EUR 193.2 |
Albumin fraction V (pH7,0) (Molecular Biology Grade) |
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| CE102 | GeneOn | 250 g | EUR 387.6 |
Albumin fraction V (pH7,0) (Molecular Biology Grade) |
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| CE103 | GeneOn | 500 g | EUR 656.4 |
Albumin fraction V (pH7,0) (Molecular Biology Grade) |
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| CE104 | GeneOn | 1 kg | EUR 1162.8 |
Water, Ultra Pure, Sterile Molecular Biology Grade |
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| 18-193 | Genesee Scientific | 100ml/Unit | EUR 268 |
Water, Ultra Pure, Sterile Molecular Biology Grade |
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| 18-194 | Genesee Scientific | 500ml/Unit | EUR 294 |
Water, Ultra Pure, Sterile Molecular Biology Grade |
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| 18-195 | Genesee Scientific | 1000ml/Unit | EUR 308 |
Water, Ultra Pure, Sterile Molecular Biology Grade |
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| 18-196 | Genesee Scientific | 4 x 1L/Unit | EUR 471 |
EDTA solution pH 8.0 (0.5 M) (Molecular Biology Grade) |
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| CE141 | GeneOn | 500 ml | EUR 87.6 |
LB-Agar - Powder according to Lennox (Molecular Biology Grade) |
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| CE178 | GeneOn | 500 g | EUR 109.2 |
LB-Agar - Powder according to Lennox (Molecular Biology Grade) |
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| CE179 | GeneOn | 2.5 kg | EUR 301.2 |
LB-Agar - Powder according to Miller (Molecular Biology Grade) |
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| CE180 | GeneOn | 500 g | EUR 104.4 |
LB-Agar - Powder according to Miller (Molecular Biology Grade) |
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| CE181 | GeneOn | 2.5 kg | EUR 295.2 |
LB-Medium - Powder according to Lennox (Molecular Biology Grade) |
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| CE182 | GeneOn | 500 g | EUR 108 |
LB-Medium - Powder according to Lennox (Molecular Biology Grade) |
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| CE183 | GeneOn | 2.5 kg | EUR 301.2 |
LB-Medium - Powder according to Miller (Molecular Biology Grade) |
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| CE184 | GeneOn | 2.5 kg | EUR 295.2 |
Agarose LE, Ultra-Pure Molecular Biology Grade, 100 g |
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| 41028-100G | Biotium | 100G | EUR 266.4 |
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Description: Minimum order quantity: 1 unit of 100G |
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Agarose LE, Ultra-Pure Molecular Biology Grade, 25 g |
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| 41028-25G | Biotium | 25G | EUR 130.8 |
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Description: Minimum order quantity: 1 unit of 25G |
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Agarose LE, Ultra-Pure Molecular Biology Grade, 500 g |
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| 41028-500G | Biotium | 500G | EUR 862.8 |
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Description: Minimum order quantity: 1 unit of 500G |
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AGAROSE LE, LOW EEO, MOLECULAR BIOLOGY GRADE, 100G PER UNIT |
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| AGR-LE-100 | CORNING | 1/pk | EUR 201.6 |
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Description: Bioscience Mol Bio; Agarose |
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Bulk Beads Zr 0.1mm Triple-Pure Molecular Biology Grade 250g |
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| HOM3048 | Scientific Laboratory Supplies | 250G | EUR 536.94 |
Bulk Beads Zr 0.5mm Triple-Pure Molecular Biology Grade 250g |
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| HOM3050 | Scientific Laboratory Supplies | 250G | EUR 536.94 |
Bulk Beads Zr 1.0mm Triple-Pure Molecular Biology Grade 250g |
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| HOM3052 | Scientific Laboratory Supplies | 250G | EUR 536.94 |
Bulk Beads Zr 1.5mm Triple-Pure Molecular Biology Grade 250g |
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| HOM3054 | Scientific Laboratory Supplies | 250G | EUR 536.94 |
Bulk Beads Zr 3.0mm Triple-Pure Molecular Biology Grade 300g |
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| HOM3056 | Scientific Laboratory Supplies | 300G | EUR 536.94 |
Sucrose |
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| abx082163-500g | Abbexa | 500 g | EUR 210 |
Sucrose |
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| abx082558-500g | Abbexa | 500 g | EUR 226.8 |
Sucrose |
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| GC4473-100G | Glentham Life Sciences | 100 g | EUR 45.6 |
Sucrose |
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| GC4473-10KG | Glentham Life Sciences | 10 kg | EUR 217.2 |
Sucrose |
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| GC4473-1KG | Glentham Life Sciences | 1 kg | EUR 64.8 |
Sucrose |
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| GC4473-250G | Glentham Life Sciences | 250 g | EUR 48 |
We additionally present new insights into the AA-induced vitality disaster and presumably a hyperlink between already recognized mechanisms. In addition, an summary of potential targets in fibrosis therapy is offered, which is adopted by suggestions on doable preventive measures that could possibly be taken to no less than postpone or partially alleviate AAN.
