Acetyl-CoA acyltransferase 1 (ACAA1) features as a key regulator of fatty acid β-oxidation in peroxisomes by catalyzing the cleavage of 3-ketoacyl-CoA to acetyl-CoA and acyl-CoA, which take part in the extension and degradation of fatty acids. Thus, ACAA1 is a vital regulator of lipid metabolism and performs a necessary function in fatty acid oxidation and lipid metabolism. Our earlier examine findings revealed that ACAA1 is intently related to the peroxisome proliferator-activated receptor (PPAR) signaling and fatty acid metabolism pathways, that are concerned in fats deposition in sheep, resulting in our speculation that ACAA1 could also be concerned in fats deposition by regulating lipid metabolism.
However, the related molecular mechanism stays unclear. In the current examine, to evaluate the potential operate of ACAA1 in sheep preadipocyte differentiation, we knocked down and overexpressed ACAA1 in sheep preadipocytes and evaluated the sample of ACAA1 gene expression throughout preadipocyte differentiation by qRT-PCR. ACAA1 was considerably expressed in the early stage of adipocyte differentiation, after which its expression decreased.
ACAA1 deficiency elevated lipid accumulation and the triglyceride content material and promoted sheep preadipocyte differentiation, whereas ACAA1 overexpression inhibited adipogenesis and decreased lipid accumulation and the triglyceride content material. Simultaneously, we demonstrated that ACAA1 deficiency upregulated the expressions of the adipogenic marker genes PPARγ and C/EBPα in sheep preadipocytes, however ACAA1 overexpression inhibited the expressions of these markers, indicating that ACAA1 impacts lipid metabolism by regulating adipogenic marker genes. Our outcomes might promote a greater understanding of the regulation of adipogenesis by ACAA1.
The molecular foundation for SARS-CoV-2 binding to canine ACE2
SARS-CoV-2 can infect many home animals, together with canines. Herein, we present that canine angiotensin-converting enzyme 2 (dACE2) can bind to the SARS-CoV-2 spike (S) protein receptor binding area (RBD), and that each pseudotyped and genuine SARS-CoV-2 can infect dACE2-expressing cells. We solved the crystal construction of RBD in advanced with dACE2 and located that the whole quantity of contact residues, contact atoms, hydrogen bonds and salt bridges at the binding interface in this advanced are barely fewer than these in the advanced of the RBD and human ACE2 (hACE2).
This result’s in line with the proven fact that the binding affinity of RBD to dACE2 is decrease than that of hACE2. We additional present that a number of vital mutations in the RBD binding interface play a pivotal function in the binding affinity of RBD to each dACE2 and hACE2. Our work reveals a molecular foundation for cross-species transmission and potential animal unfold of SARS-CoV-2, and offers new clues to dam the potential transmission chains of this virus.
Ependymal cells-CSF circulate regulates stress-induced melancholy
Major depressive dysfunction (MDD) is a extreme, widespread temper dysfunction. While decreased cerebrospinal fluid (CSF) circulate adversely impacts mind metabolism and fluid stability in the growing older inhabitants and through improvement, solely oblique proof hyperlinks aberrant CSF circulation with many ailments together with neurological, neurodegenerative, and psychiatric issues, resembling nervousness and melancholy. Here we present a really excessive focus of p11 as a key molecular determinant for melancholy in ependymal cells, which is considerably decreased in sufferers with MDD, and in two mouse fashions of melancholy induced by continual stress, resembling restraint and social isolation.
The loss of p11 in ependymal cells causes disoriented ependymal planar cell polarity (PCP), decreased CSF circulate, and depression-like and anxiety-like behaviors. p11 intrinsically controls PCP core genes, which mediates CSF circulate. Viral expression of p11 in ependymal cells particularly rescues the pathophysiological and behavioral deficits brought on by loss of p11. Taken collectively, our outcomes determine a brand new function and a key molecular determinant for ependymal cell-driven CSF circulate in temper issues and recommend a novel technique for improvement of therapies for stress-associated neurological, neurodegenerative, and psychiatric issues.
Differential binding of SARS-CoV-2 Spike protein variants to its cognate receptor hACE2 utilizing molecular modeling based mostly binding evaluation
The present emergence of novel coronavirus, SARS-CoV-2 and its ceaseless enlargement worldwide has posed a worldwide well being emergency that has adversely affected the people. With the total world striving to grasp the newly emerged virus, variations in morbidity and an infection fee of SARS-CoV-2 have been noticed throughout diverse geographic areas, which have been ascribed to viral mutation and evolution over time. The homotrimeric Spike (S) glycoprotein on the viral envelope floor is accountable for binding, priming, and initiating an infection in the host.
Our phylogeny evaluation of 1947 sequences of S proteins indicated there’s a change in amino acid (aa) from aspartate (Group-A) to glycine (Group-B) at place 614, close to the receptor- binding area (RBD; aa positions 331-524). The two variants are reported to be in circulation, disproportionately throughout the world, with Group-A dominant in Asia and Group-B in North America.
The trimeric, monomeric, and RBD of S protein of each the variant teams (A & B) have been modeled utilizing the Swiss-Model server and have been docked with the human receptor angiotensin-converting enzyme 2 (hACE2) using the PatchDock server and visualized in PyMol. Group-A S protein’s RBD certain imperceptibly to the two binding clefts of the hACE2 protein, on the different hand, Group-B S protein’s RBD completely interacted inside the binding clefts of hACE2, with larger quantity of hydrogen and hydrophobic interactions.
BCIP (Molecular Biology Grade) |
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| CE109 | GeneOn | 1 g | EUR 90 |
CHAPS (Molecular Biology Grade) |
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| CE114 | GeneOn | 1 g | EUR 55 |
CHAPS (Molecular Biology Grade) |
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| CE115 | GeneOn | 5 g | EUR 131 |
CHAPS (Molecular Biology Grade) |
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| CE116 | GeneOn | 25 g | EUR 410 |
DAPI (Molecular Biology Grade) |
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| CE117 | GeneOn | 5 mg | EUR 60 |
DAPI (Molecular Biology Grade) |
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| CE118 | GeneOn | 25 mg | EUR 133 |
DAPI (Molecular Biology Grade) |
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| CE119 | GeneOn | 100 mg | EUR 319 |
Dimethylsulfoxide (Molecular Biology Grade) |
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| CE120 | GeneOn | 100 ml | EUR 55 |
Dimethylsulfoxide (Molecular Biology Grade) |
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| CE121 | GeneOn | 500 ml | EUR 92 |
DTT (Molecular Biology Grade) |
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| CE131 | GeneOn | 5 g | EUR 78 |
DTT (Molecular Biology Grade) |
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| CE132 | GeneOn | 10 g | EUR 111 |
DTT (Molecular Biology Grade) |
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| CE133 | GeneOn | 25 g | EUR 203 |
Glycine (Molecular Biology Grade) |
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| CE158 | GeneOn | 1 kg | EUR 70 |
Glycine (Molecular Biology Grade) |
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| CE159 | GeneOn | 5 kg | EUR 190 |
HEPES (Molecular Biology Grade) |
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| CE171 | GeneOn | 100 g | EUR 82 |
HEPES (Molecular Biology Grade) |
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| CE172 | GeneOn | 500 g | EUR 224 |
HEPES (Molecular Biology Grade) |
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| CE173 | GeneOn | 1 kg | EUR 354 |
Lysozyme (Molecular Biology Grade) |
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| CE188 | GeneOn | 1 g | EUR 59 |
Lysozyme (Molecular Biology Grade) |
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| CE189 | GeneOn | 10 g | EUR 206 |
NAD (Molecular Biology Grade) |
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| CE196 | GeneOn | 1 g | EUR 60 |
NAD (Molecular Biology Grade) |
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| CE197 | GeneOn | 5 g | EUR 138 |
NBT (Molecular Biology Grade) |
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| CE209 | GeneOn | 1 g | EUR 103 |
NBT (Molecular Biology Grade) |
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| CE210 | GeneOn | 5 g | EUR 300 |
Tris (Molecular Biology Grade) |
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| CE237 | GeneOn | 500 g | EUR 89 |
Tris (Molecular Biology Grade) |
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| CE238 | GeneOn | 1 kg | EUR 128 |
Tris (Molecular Biology Grade) |
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| CE239 | GeneOn | 5 kg | EUR 446 |
Tween20 (Molecular Biology Grade) |
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| CE242 | GeneOn | 1 l | EUR 89 |
Water (Molecular Biology Grade) |
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| CE243 | GeneOn | 500 ml | EUR 52 |
Water (Molecular Biology Grade) |
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| CE244 | GeneOn | 1 l | EUR 56 |
Water, Ultrapure Molecular Biology Grade |
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| 41024-4L | Biotium | 4L | EUR 121 |
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Description: Minimum order quantity: 1 unit of 4L |
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Ammonium sulfate (Molecular Biology Grade) |
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| CE105 | GeneOn | 250 g | EUR 46 |
Ammonium sulfate (Molecular Biology Grade) |
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| CE106 | GeneOn | 1 kg | EUR 60 |
Ammonium sulfate (Molecular Biology Grade) |
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| CE107 | GeneOn | 5 kg | EUR 128 |
Bis-Acrylamid (Molecular Biology Grade) |
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| CE110 | GeneOn | 50 g | EUR 79 |
Bis-Acrylamid (Molecular Biology Grade) |
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| CE111 | GeneOn | 250 g | EUR 216 |
Formamide deionized (Molecular Biology Grade) |
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| CE145 | GeneOn | 500 ml | EUR 73 |
Formamide deionized (Molecular Biology Grade) |
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| CE146 | GeneOn | 1 l | EUR 100 |
Glycerol 87 % (Molecular Biology Grade) |
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| CE154 | GeneOn | 1 l | EUR 78 |
Glycerol waterfree (Molecular Biology Grade) |
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| CE155 | GeneOn | 500 ml | EUR 65 |
Glycerol waterfree (Molecular Biology Grade) |
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| CE156 | GeneOn | 1 l | EUR 85 |
Glycerol waterfree (Molecular Biology Grade) |
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| CE157 | GeneOn | 2.5 l | EUR 142 |
Guanidine - Hydrochloride (Molecular Biology Grade) |
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| CE160 | GeneOn | 100 g | EUR 78 |
Guanidine - Hydrochloride (Molecular Biology Grade) |
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| CE161 | GeneOn | 250 g | EUR 128 |
Guanidine - Hydrochloride (Molecular Biology Grade) |
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| CE162 | GeneOn | 500 g | EUR 194 |
Guanidine - Hydrochloride (Molecular Biology Grade) |
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| CE163 | GeneOn | 1 kg | EUR 294 |
Guanidine Thiocyanate (Molecular Biology Grade) |
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| CE164 | GeneOn | 100 g | EUR 72 |
Guanidine Thiocyanate (Molecular Biology Grade) |
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| CE165 | GeneOn | 500 g | EUR 160 |
Guanidine Thiocyanate (Molecular Biology Grade) |
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| CE166 | GeneOn | 1 kg | EUR 256 |
MOPS buffer (Molecular Biology Grade) |
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| CE194 | GeneOn | 100 g | EUR 85 |
MOPS buffer (Molecular Biology Grade) |
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| CE195 | GeneOn | 250 g | EUR 141 |
Sodium chloride (Molecular Biology Grade) |
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| CE205 | GeneOn | 500 g | EUR 52 |
Sodium chloride (Molecular Biology Grade) |
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| CE206 | GeneOn | 1 kg | EUR 59 |
Sodium chloride (Molecular Biology Grade) |
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| CE207 | GeneOn | 5 kg | EUR 103 |
D(+)-Sucrose (Molecular Biology Grade) |
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| CE224 | GeneOn | 500 g | EUR 56 |
D(+)-Sucrose (Molecular Biology Grade) |
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| CE225 | GeneOn | 1 kg | EUR 70 |
D(+)-Sucrose (Molecular Biology Grade) |
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| CE226 | GeneOn | 5 kg | EUR 173 |
Tris - Hydrochloride (Molecular Biology Grade) |
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| CE234 | GeneOn | 250 g | EUR 83 |
Tris - Hydrochloride (Molecular Biology Grade) |
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| CE235 | GeneOn | 500 g | EUR 120 |
Tris - Hydrochloride (Molecular Biology Grade) |
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| CE236 | GeneOn | 1 kg | EUR 186 |
TritonX-100 (Molecular Biology Grade) |
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| CE240 | GeneOn | 500 ml | EUR 56 |
TritonX-100 (Molecular Biology Grade) |
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| CE241 | GeneOn | 1 l | EUR 66 |
Tween 20, Molecular Biology Grade |
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| T9100-010 | GenDepot | 100ml | EUR 72 |
Tween 20, Molecular Biology Grade |
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| T9100-050 | GenDepot | 500ml | EUR 111 |
Tween 20, Molecular Biology Grade |
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| T9100-100 | GenDepot | 1L | EUR 134 |
Agarose, low EEO, GlenBiol, suitable for molecular biology |
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| GE6258-100G | Glentham Life Sciences | 100 g | EUR 181 |
Water, distilled, GlenBiol™, suitable for molecular biology |
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| GK8512-1L | Glentham Life Sciences | 1 l | EUR 77 |
Crystalline |
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| 5-01010 | CHI Scientific | 10mg | Ask for price |
EDTA - Dinatriumsalz - Dihydrat (Molecular Biology Grade) |
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| CE135 | GeneOn | 250 g | EUR 60 |
EDTA - Dinatriumsalz - Dihydrat (Molecular Biology Grade) |
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| CE136 | GeneOn | 500 g | EUR 72 |
EDTA - Dinatriumsalz - Dihydrat (Molecular Biology Grade) |
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| CE137 | GeneOn | 1 kg | EUR 104 |
EDTA - Dinatriumsalz - Dihydrat (Molecular Biology Grade) |
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| CE138 | GeneOn | 5 kg | EUR 349 |
D(+)-Glucose waterfree (Molecular Biology Grade) |
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| CE148 | GeneOn | 500 g | EUR 56 |
D(+)-Glucose waterfree (Molecular Biology Grade) |
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| CE149 | GeneOn | 1 kg | EUR 63 |
D(+)-Glucose waterfree (Molecular Biology Grade) |
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| CE150 | GeneOn | 5 kg | EUR 150 |
Yeast extract powder (Molecular Biology Grade) |
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| CE169 | GeneOn | 500 g | EUR 111 |
Hyaluronidase Grade I (Molecular Biology Grade) |
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| CE174 | GeneOn | 1 g | EUR 194 |
Hyaluronidase Grade I (Molecular Biology Grade) |
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| CE175 | GeneOn | 5 g | EUR 767 |
Magnesium acetate - Tetrahydrate (Molecular Biology Grade) |
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| CE190 | GeneOn | 500 g | EUR 82 |
NADH - Disodium salt (Molecular Biology Grade) |
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| CE198 | GeneOn | 1 g | EUR 76 |
NADH - Disodium salt (Molecular Biology Grade) |
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| CE199 | GeneOn | 5 g | EUR 204 |
NADP - sodium salt (Molecular Biology Grade) |
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| CE200 | GeneOn | 250 mg | EUR 77 |
NADP - sodium salt (Molecular Biology Grade) |
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| CE201 | GeneOn | 1 g | EUR 159 |
NADPH - Tetrasodium salt (Molecular Biology Grade) |
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| CE202 | GeneOn | 25 mg | EUR 59 |
NADPH - Tetrasodium salt (Molecular Biology Grade) |
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| CE203 | GeneOn | 100 mg | EUR 105 |
NADPH - Tetrasodium salt (Molecular Biology Grade) |
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| CE204 | GeneOn | 500 mg | EUR 312 |
SSC Buffer (20X) (Molecular Biology Grade) |
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| CE229 | GeneOn | 1 l | EUR 72 |
XTT sodium salt (Molecular Biology Grade) |
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| CE250 | GeneOn | 100 mg | EUR 174 |
XTT sodium salt (Molecular Biology Grade) |
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| CE251 | GeneOn | 500 mg | EUR 510 |
Albumin fraction V (pH7,0) (Molecular Biology Grade) |
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| CE100 | GeneOn | 50 g | EUR 107 |
Albumin fraction V (pH7,0) (Molecular Biology Grade) |
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| CE101 | GeneOn | 100 g | EUR 161 |
Albumin fraction V (pH7,0) (Molecular Biology Grade) |
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| CE102 | GeneOn | 250 g | EUR 323 |
Albumin fraction V (pH7,0) (Molecular Biology Grade) |
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| CE103 | GeneOn | 500 g | EUR 547 |
Albumin fraction V (pH7,0) (Molecular Biology Grade) |
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| CE104 | GeneOn | 1 kg | EUR 969 |
Agarose LE, Ultra-Pure Molecular Biology Grade, 100 g |
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| 41028-100G | Biotium | 100G | EUR 222 |
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Description: Minimum order quantity: 1 unit of 100G |
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Agarose LE, Ultra-Pure Molecular Biology Grade, 25 g |
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| 41028-25G | Biotium | 25G | EUR 109 |
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Description: Minimum order quantity: 1 unit of 25G |
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Agarose LE, Ultra-Pure Molecular Biology Grade, 500 g |
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| 41028-500G | Biotium | 500G | EUR 719 |
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Description: Minimum order quantity: 1 unit of 500G |
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EDTA solution pH 8.0 (0.5 M) (Molecular Biology Grade) |
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| CE141 | GeneOn | 500 ml | EUR 73 |
LB-Agar - Powder according to Lennox (Molecular Biology Grade) |
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| CE178 | GeneOn | 500 g | EUR 91 |
LB-Agar - Powder according to Lennox (Molecular Biology Grade) |
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| CE179 | GeneOn | 2.5 kg | EUR 251 |
LB-Agar - Powder according to Miller (Molecular Biology Grade) |
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| CE180 | GeneOn | 500 g | EUR 87 |
LB-Agar - Powder according to Miller (Molecular Biology Grade) |
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| CE181 | GeneOn | 2.5 kg | EUR 246 |
LB-Medium - Powder according to Lennox (Molecular Biology Grade) |
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| CE182 | GeneOn | 500 g | EUR 90 |
LB-Medium - Powder according to Lennox (Molecular Biology Grade) |
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| CE183 | GeneOn | 2.5 kg | EUR 251 |
LB-Medium - Powder according to Miller (Molecular Biology Grade) |
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| CE184 | GeneOn | 2.5 kg | EUR 246 |
AGAROSE LE, LOW EEO, MOLECULAR BIOLOGY GRADE, 100G PER UNIT |
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| AGR-LE-100 | CORNING | 1/pk | EUR 168 |
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Description: Bioscience Mol Bio; Agarose |
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Phenol |
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| 20-abx184753 | Abbexa |
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100 ML, MOLECULAR BIOLOGY GRADE WATER; TESTED TO USP STERILE PURIFIED WATER SPECIFICATIONS |
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| 46-000-CI | CORNING | 100 mL/pk | EUR 57 |
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Description: Media Catalog; Sterile Wi-Fi Qual, Cell |
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1 L, MOLECULAR BIOLOGY GRADE WATER; TESTED TO USP STERILE PURIFIED WATER SPECIFICATIONS |
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| 46-000-CM | CORNING | 1L/pk | EUR 98 |
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Description: Media Catalog; Sterile Wi-Fi Qual, Cell |
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500 ML, MOLECULAR BIOLOGY GRADE WATER; TESTED TO USP STERILE PURIFIED WATER SPECIFICATIONS |
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| 46-000-CV | CORNING | 500 mL/pk | EUR 106 |
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Description: Media Catalog; Sterile Wi-Fi Qual, Cell |
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AGAROSE LE, LOW EEO, MOLECULAR BIOLOGY GRADE, 500G/UNIT, 10 UNITS PER CASE |
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| AGR-LE-5001 | CORNING | 1/pk | EUR 3058 |
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Description: Bioscience Mol Bio; Agarose |
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AGAROSE MS, PCR SCREENING, MOLECULAR BIOLOGY GRADE, 100G/UNIT, 10 UNITS PER CASE |
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| AGR-MS-1001 | CORNING | 1/pk | EUR 2038 |
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Description: Bioscience Mol Bio; Agarose |
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Crystalline [H-Trp-Gly-OH; MW: 261.2] |
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| SP-55342-1 | Alpha Diagnostics | 1 mg | EUR 141 |
Phenol red |
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| PB0420 | Bio Basic | 25g | EUR 70.88 |
Phenol, 99% |
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| GK6990-100G | Glentham Life Sciences | 100 g | EUR 44 |
Phenol, 99% |
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| GK6990-1KG | Glentham Life Sciences | 1 kg | EUR 78 |
Phenol, 99% |
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| GK6990-500G | Glentham Life Sciences | 500 g | EUR 56 |
Phenol Red |
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| GT9844-100G | Glentham Life Sciences | 100 g | EUR 110 |
Phenol Red |
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| GT9844-250G | Glentham Life Sciences | 250 g | EUR 181 |
Phenol Red |
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| GT9844-25G | Glentham Life Sciences | 25 g | EUR 62 |
Phenol Red |
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| GT9844-5G | Glentham Life Sciences | 5 g | EUR 46 |
Nonyl Phenol |
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| AT037 | Unibiotest | 1mg | EUR 1368 |
Nonyl Phenol |
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| AG037 | Unibiotest | 1 mg | EUR 523 |
Water Phenol |
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| abx082109-250ml | Abbexa | 250 ml | EUR 189 |
AGAROSE LE, LOW EEO, MOLECULAR BIOLOGY GRADE, 100G PER UNIT, 10 UNITS PER CASE |
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| AGR-LE-1001 | CORNING | 1/pk | EUR 772 |
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Description: Bioscience Mol Bio; Agarose |
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AGAROSE LM, LOW MELTING, MOLECULAR BIOLOGY GRADE, 100G/UNIT, 10 UNITS PER CASE (AL) |
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| AGR-LM-1001 | CORNING | 1/pk | EUR 3737 |
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Description: Bioscience Mol Bio; Agarose |
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AGAROSE LM, LOW MELTING, MOLECULAR BIOLOGY GRADE, 50G/UNIT, 10 UNITS PER CASE (AL) |
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| AGR-LM-501 | CORNING | 1/pk | EUR 2075 |
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Description: Bioscience Mol Bio; Agarose |
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ELISA kit for Rat PST (Phenol Sulfotransferase) |
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| ELK6740 | ELK Biotech | 1 plate of 96 wells | EUR 432 |
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Description: A sandwich ELISA kit for detection of Phenol Sulfotransferase from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
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ELISA kit for Human PST (Phenol Sulfotransferase) |
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| ELK3246 | ELK Biotech | 1 plate of 96 wells | EUR 432 |
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Description: A sandwich ELISA kit for detection of Phenol Sulfotransferase from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
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ELISA kit for Mouse PST (Phenol Sulfotransferase) |
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| ELK3642 | ELK Biotech | 1 plate of 96 wells | EUR 432 |
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Description: A sandwich ELISA kit for detection of Phenol Sulfotransferase from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
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Phenol, saturated (pH7.9) |
|||
| PC6910 | Bio Basic | 100ml | EUR 76.1 |
Phenol, saturated (pH4.5) |
|||
| PC6920 | Bio Basic | 100ml | EUR 76.1 |
4-(Benzyloxy)phenol |
|||
| GP9986-100G | Glentham Life Sciences | 100 g | EUR 118 |
4-(Benzyloxy)phenol |
|||
| GP9986-250G | Glentham Life Sciences | 250 g | EUR 198 |
4-(Benzyloxy)phenol |
|||
| GP9986-25G | Glentham Life Sciences | 25 g | EUR 59 |
Phenol Red Solution |
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| CA013-010 | GenDepot | 100ml | EUR 69 |
3-(Aminomethyl)phenol |
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| 20-abx185751 | Abbexa |
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Phenol, 4-propoxy- |
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| 20-abx184303 | Abbexa |
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2-(Aminomethyl)phenol |
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| 20-abx185699 | Abbexa |
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30UL CLEAR PIPET TIPS FOR MOLECULAR DEVICE LIBERTY. |
|||
| LT-384-R | CORNING | 3840/pk | EUR 2193 |
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Description: Robotic Tips; Robotic tips - Axygen |
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Recombinant Phenol Sulfotransferase (PST) |
|||
| 4-RPB268Hu01 | Cloud-Clone |
|
|
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Description: Recombinant Human Phenol Sulfotransferase expressed in: E.coli |
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Recombinant Phenol Sulfotransferase (PST) |
|||
| 4-RPB268Mu01 | Cloud-Clone |
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|
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Description: Recombinant Mouse Phenol Sulfotransferase expressed in: E.coli |
|||
Recombinant Phenol Sulfotransferase (PST) |
|||
| 4-RPB268Ra01 | Cloud-Clone |
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Description: Recombinant Rat Phenol Sulfotransferase expressed in: E.coli |
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Phenol red, sodium salt |
|||
| PD0424 | Bio Basic | 25g | EUR 63.92 |
Phenol Red (sodium salt) |
|||
| HY-D0169A | MedChemExpress | 500mg | EUR 108 |
This implies that the S protein’s amino acid at place 614 close to the core RBD influences its interplay with the cognate hACE2 receptor, which can induce its infectivity that ought to be explored additional with molecular and biochemical research.
